From somatic mutations to ranked vaccine targets in minutes. Upload VCF, MAF, or CSV. Get MHC binding predictions, cleavage scores, and immunogenicity rankings.
VCF (VEP, SnpEff, DRAGEN), TCGA MAF, or pre-processed CSV with protein changes.
Extract coding somatic variants. Filter by consequence, VAF, read depth.
MHCflurry predicts binding affinity, presentation score, and cleavage probability per HLA allele.
Multi-factor scoring combining binding, expression, VAF, and sequence properties.
Handles output from all major annotation pipelines. Robust parsing, informative error messages, and transparent scoring.
VCF with VEP, SnpEff, Funcotator, DRAGEN, or Nirvana annotations. TCGA MAF format. Pre-processed CSV. Optional RNA expression matrices.
MHCflurry 2.0 binding, presentation, and processing scores. Validated against published benchmarks. Supports 150+ HLA-A/B/C alleles.
Each epitope score is decomposable: binding weight, expression weight, VAF contribution, and sequence features. No black boxes.
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